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Venlafaxine
Clinical data
Trade namesEffexor, many generics [1]
AHFS/Drugs.comMonograph
License dataUS  DailyMed:  b23637e5-d37f-41b5-ba76-fc053e903bc2
Pregnancy categoryAU: B2 US: C (Risk not ruled out)
Routes of administrationby mouth
ATC codeN06AX16 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability42±15% [2]
Protein binding27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine) [3]
MetabolismHepatic (~50% of the parent compound is metabolised on first pass through the liver) [2] [3]
Elimination half-life5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite) [2] [3]
ExcretionRenal (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites) [2] [3]

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